Dr. Papa Kwesi Nduom started full-time work after the obtaining his bachelor's degree as a Life Insurance Underwriter with the Northwestern Mutual Life Insurance Company. He changed jobs and worked for Blue Cross Blue Shield of Wisconsin and the Milwaukee Metropolitan Sewerage District before he joined Deloitte & Touche (then Touche Ross) in 1981 as an Associate Consultant. Dr. Nduom moved rapidly through the ranks at Deloitte & Touche and became a Partner of the firm in the Milwaukee office in 1986. Out of over 1000 partners, Dr. Nduom was one of five blacks who were partners in 1986. In 1988, he was transferred to the Washington, DC office of Deloitte & Touche. In 1992, he established Deloitte & Touche, West Africa Consulting after spending two years commuting between Ghana and Washington, DC on various consulting assignments.

The firm he established, was a non-territorial consulting practice that in a very short period of time provided management consulting services to many major national and multi-national companies in the African region.

Within five years of its establishment, the firm had over 80 professionals based in Ghana, Cameroun, Nigeria, Liberia, Cote d'Ivoire and worked in Africa, Middle East and the USA. The major clients of the firm included Ashanti Goldfields Company, African Development Bank, Texaco, Elf Oil, African Reinsurance, Zimbabwe National Social Security Authority, Ghana Telecom, Nestle, Unilever and Malawi Oil Company and others. Dr. Nduom has also served as the Coordinator of Management Consulting for the African Region. Dr. Nduom holds a certificate in Management from Marquette University, a Certificate in Insurance from the Life Office Management Institute in the USA, and is a Certified Management Consultant (CMC) of the Institute of Management Consultants, Washington, DC.